•The Good Signal
A pathology AI matched FDA-cleared cancer detectors
Vorontsov et al. in Nature Medicine (31 July 2026) trained PRISM2 on 2,350,518 whole-slide images from 685,507 specimens and 200,692 patients, plus 14 million question–answer pairs. Prompt-based inference matches or exceeds (P < 0.05) Paige Prostate, Paige Breast and Paige BLN on their own test sets. Pan-cancer linear-probe AUC 0.967. Not a prospective reader trial.