•The Good Signal
An AI lung drug made six aging clocks run younger
On 7 September 2026, Insilico Medicine and collaborators published in Nature Biotechnology a Phase IIa exploratory analysis showing that rentosertib, an AI-designed TNIK inhibitor for idiopathic pulmonary fibrosis, lowered predicted biological age on all six proteomic aging clocks tested in 42 patients. Peak signal was about 3–4 years younger at week 4 on 30 mg twice daily — exploratory biomarkers in sick lungs, not an approved anti-aging pill.